{"id":545424,"date":"2026-08-27T06:41:43","date_gmt":"2026-08-27T04:41:43","guid":{"rendered":"https:\/\/dev.phytocontrol.com\/uncategorized\/new-multi-alkaloid-assay-method\/"},"modified":"2026-09-20T13:00:54","modified_gmt":"2026-09-20T11:00:54","slug":"new-multi-alkaloid-assay-method","status":"publish","type":"post","link":"https:\/\/dev.phytocontrol.com\/en\/regulatory-watch\/new-multi-alkaloid-assay-method\/","title":{"rendered":"New multi-alkaloid assay method!"},"content":{"rendered":"<p><img decoding=\"async\" class=\"aligncenter wp-image-383 size-full\" src=\"http:\/\/phytocontrol.s3.amazonaws.com\/wp-content\/uploads\/2014\/05\/1386942155.alcaloides.png\" alt=\"New multi-alkaloid assay method!\" width=\"400\" height=\"120\" \/><\/p>\n<p style=\"text-align: justify;\">PHYTOCONTROL is pleased to announce that its R&amp;D department has recently developed a new, innovative UFLC method enabling the simultaneous assay of ergot alkaloids and Datura alkaloids with limits of quantification of 1 to 5 \u00b5g\/kg!<\/p>\n<p style=\"text-align: justify;\">The term ergot refers to the fungal structures of the species Claviceps, which replace grains on cereal ears or grass inflorescence seeds and appear as large, dark-coloured sclerotia. These sclerotia contain various classes of alkaloids, the most important of which are ergometrine, ergotamine, ergosine, ergocristine, ergocryptine and ergocornine and their -inine derivatives.<\/p>\n<p style=\"text-align: justify;\">EU recommendation No. 2012\/154, published on 15 March 2012, introduced the need to use chromatographic methods to determine the levels of certain ergot alkaloids not only in raw cereals but also in cereal-based products. According to this same recommendation, member states should test for, at minimum, the following ergot alkaloids:<\/p>\n<ul>\n<li style=\"text-align: justify;\">ergocristine\/ergocristinine,<\/li>\n<li style=\"text-align: justify;\">ergotamine\/ergotaminine,<\/li>\n<li style=\"text-align: justify;\">ergocryptine\/ergocryptinine,<\/li>\n<li style=\"text-align: justify;\">ergometrine\/ergometrinine,<\/li>\n<li style=\"text-align: justify;\">ergosine\/ergosinine,<\/li>\n<li style=\"text-align: justify;\">ergocornine\/ergocorninine.<\/li>\n<\/ul>\n<p style=\"text-align: justify;\">Regarding Datura alkaloids, AFSSA published an opinion on 18 February 2009 on the presence of atropine and scopolamine as undesirable substances in buckwheat flour intended for human consumption, and on the relevance of the provisional management threshold proposed by the DGCCRF.<\/p>\n<p style=\"text-align: justify;\">Datura (Datura stramonium L.) is an annual herbaceous plant of the Solanaceae family found in fields, which produces tropane alkaloids whose main compounds are a mixture of atropine and scopolamine, substances with a parasympatholytic effect.<\/p>\n<p style=\"text-align: justify;\">In its opinion, AFSSA set an intervention threshold of 100 \u03bcg\/kg in buckwheat flour for the sum of Datura alkaloids.<\/p>\n<p style=\"text-align: justify;\">For any technical, pricing or regulatory information, please contact your regional PHYTOCONTROL office.<\/p>\n<p>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>PHYTOCONTROL is pleased to announce that its R&amp;D department has recently developed a new, innovative&hellip;<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"gallery","meta":{"_acf_changed":false,"footnotes":""},"categories":[181],"tags":[],"class_list":["post-545424","post","type-post","status-publish","format-gallery","hentry","category-regulatory-watch","post_format-post-format-gallery"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.4 (Yoast SEO v28.5) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>New multi-alkaloid assay method! 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