opinion<\/a> from ANSES regarding the relevance classification of the chlorothalonil metabolites R417888 and R471811 in drinking water has recently been published.<\/p>\n\nANSES was asked to assess the relevance of these two chlorothalonil metabolites for drinking water. This assessment is based on a methodology developed by ANSES, including European data, a literature review, and information provided by Syngenta, the holder of authorisations for chlorothalonil-based products.<\/p>\n\n
For the metabolite R417888, the available data did not rule out its potential genotoxicity, and it was classified as “relevant for drinking water”.<\/p>\n\n
Regarding the metabolite R471811, an initial ANSES assessment led to it being considered “relevant for drinking water” (ANSES opinion of 26 January 2022) at the carcinogenicity assessment stage. In the absence of data available on this metabolite, the potential carcinogenic effects of the parent substance, chlorothalonil, were taken into account. Based on EFSA’s proposed classification of the active substance as a category 1B carcinogen, and in the absence of data demonstrating that the metabolite R471811 did not share chlorothalonil’s mode of action, its relevance was proposed.<\/p>\n\n
The analysis of new knowledge, including data provided by the declarant and the literature review carried out by experts, made it possible to determine that this metabolite most probably does not share chlorothalonil’s nephrotoxic mode of action.<\/p>\n\n
As a result, it has been reclassified as “not relevant for drinking water”.<\/p>\n\n
As a reminder, the regulatory values applicable for the health control and monitoring of drinking water are:<\/p>\n\n
– a quality limit of 0.1 \u03bcg\/L for relevant metabolites;<\/p>\n\n
– an indicative value of 0.9 \u03bcg\/L for non-relevant metabolites.<\/p>\n\n
Please note that Phytocontrol holds the national approval from the Ministry of Health and the Environment for carrying out sampling and analysis for water health control.<\/p>\n\n
You will find the details of our accreditations in our COFRAC technical annex No. 1-6066.<\/p>\n\n
Need technical, regulatory or pricing information? Our customer service is available from 8 a.m. to 8 p.m., Monday to Friday, at +33 800 900 775 or service-clients@phytocontrol.com<\/a>.<\/p>\n\nAnd to stay up to date with all Phytocontrol news, join us on our LinkedIn page!<\/p>\n","protected":false},"excerpt":{"rendered":"
A new opinion from ANSES regarding the relevance classification of the chlorothalonil metabolites R417888 and…<\/p>\n","protected":false},"author":8,"featured_media":30476,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[181],"tags":[],"class_list":["post-544243","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-regulatory-watch"],"acf":[],"yoast_head":"\n
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