{"id":21623,"date":"2021-02-16T10:01:58","date_gmt":"2021-02-16T09:01:58","guid":{"rendered":"https:\/\/www.phytocontrol.com\/?p=21623"},"modified":"2026-08-28T00:24:00","modified_gmt":"2026-08-27T22:24:00","slug":"anses-opinion-on-the-relevance-of-metabolites-in-edchs","status":"publish","type":"post","link":"https:\/\/dev.phytocontrol.com\/en\/regulatory-watch\/anses-opinion-on-the-relevance-of-metabolites-in-edchs\/","title":{"rendered":"ANSES opinion on the relevance of metabolites in drinking water"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><\/p>\n\n<p class=\"wp-block-paragraph\">On 2 February 2021, ANSES published an <a href=\"https:\/\/www.anses.fr\/fr\/system\/files\/EAUX2019SA0129.pdf\">Opinion on determining the relevance for water intended for human consumption of pesticide metabolites: metolachlor OXA (CGA 51202), metolachlor ESA (CGA 354743) and metolachlor NOA 413173 (SYN 547627)<\/a>.<\/p>\n\n<p class=\"wp-block-paragraph\">The presence of pesticide residues and their metabolites in water is governed by European Directive 98\/83\/EC on the quality of water intended for human consumption.<\/p>\n\n<p class=\"wp-block-paragraph\">This text requires the monitoring of relevant pesticides and their metabolites and sets quality limits in drinking water at 0.1\u00b5g\/L per individual substance and 0.5\u00b5g\/L for the sum.<\/p>\n\n<p class=\"wp-block-paragraph\">However, the directive does not provide criteria for identifying the relevance of a metabolite.<\/p>\n\n<p class=\"wp-block-paragraph\">The lack of a precise definition leads to different strategies from one member state to another.<\/p>\n\n<p class=\"wp-block-paragraph\">The concept of relevance in drinking water is not defined in French regulations; the current position is to consider all detected pesticide metabolites as relevant.<\/p>\n\n<p class=\"wp-block-paragraph\">Therefore, in order to address local management issues, the DGS asked ANSES to define and establish criteria for assessing the relevance of pesticide metabolites in drinking water (referral No. 2015-SA0252). We previously shared with you the <a href=\"https:\/\/www.phytocontrol.com\/veille-reglementaire\/avis-de-lanses-sur-la-pertinence-des-metabolites-de-pesticides-dans-les-eaux-de-consommation\/\">results of this work following the publication of the Opinion of 30 January 2019<\/a>.<\/p>\n\n<p class=\"wp-block-paragraph\">As part of that opinion, the ESA (CGA 354743) and OXA (CGA 51202) metabolites of S-metolachlor had been classified as &#8220;relevant for drinking water&#8221; due to a lack of data on their &#8220;pesticide&#8221; activity and a lack of robustness in certain data, which prevented conclusions on their genotoxic potential.<\/p>\n\n<p class=\"wp-block-paragraph\">This assessment was carried out while the European re-evaluation procedure for S-metolachlor was underway. Since then, additional data has been submitted by the notifier at EFSA&#8217;s request as part of this European procedure.<\/p>\n\n<p class=\"wp-block-paragraph\">The DGS then asked ANSES to reassess the relevance of metolachlor ESA (CGA 354743) and metolachlor OXA (CGA 51202) in light of this new data, and to assess the relevance of a third metolachlor metabolite, metolachlor NOA 413173 (SYN 547627).<\/p>\n\n<p class=\"wp-block-paragraph\">Based on the additional European data and the supplementary literature search conducted, and according to the methodology developed in the opinion of 30 January 2019 (decision tree for determining relevance), here are the conclusions of the &#8220;Water&#8221; Expert Committee (CES):<\/p>\n\n<p class=\"wp-block-paragraph\">&#8211; metolachlor OXA (CGA 51202) is considered a non-relevant metabolite for drinking water.<\/p>\n\n<p class=\"wp-block-paragraph\">&#8211; metolachlor ESA (CGA 354743) and metolachlor NOA 413173 (SYN 547627) are considered relevant metabolites for drinking water.<\/p>\n\n<p class=\"wp-block-paragraph\">Phytocontrol holds the national approval of the Ministry of Health for carrying out sampling and analysis for the sanitary control of water.<\/p>\n\n<p class=\"wp-block-paragraph\">We offer analysis of a wide range of pesticides and metabolites in your fresh water, natural mineral water and carbonated water. You will find details of our accreditations in our COFRAC technical annex No. 1-6066.<\/p>\n\n<p class=\"wp-block-paragraph\">Need technical, regulatory or pricing information? Our customer service is available from 8am to 8pm, Monday to Friday, at <a href=\"tel:+33800900775\">+33 800 900 775<\/a> or <a href=\"mailto:service-clients@phytocontrol.com\">service-clients@phytocontrol.com<\/a><\/p>\n\n<p class=\"wp-block-paragraph\">And to stay up to date with all Phytocontrol news, join us on our <a href=\"https:\/\/www.linkedin.com\/company\/laboratoire-phytocontrol\/\" target=\"_blank\" rel=\"noreferrer noopener\">LinkedIn<\/a> and <a href=\"https:\/\/www.facebook.com\/laboratoirePHYTOCONTROL\" target=\"_blank\" rel=\"noreferrer noopener\">Facebook<\/a> pages!<\/p>\n","protected":false},"excerpt":{"rendered":"<p>On 2 February 2021, ANSES published an Opinion on determining the relevance for water intended&hellip;<\/p>\n","protected":false},"author":2,"featured_media":14526,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[181],"tags":[],"class_list":["post-21623","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-regulatory-watch"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.4 (Yoast SEO v28.5) - 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